Table 4.
Percentage changes (95% CIs) in serum concentrations of sex hormones for a doubling in PFAS concentrations that were selected in adaptive elastic-net models.
| Selected PFAS in adaptive elastic-net | Percentage change (95% CI) |
|---|---|
| FSH | |
| n-PFOA | 2.27 (0.26, 4.32)** |
| E2 | |
| n-PFOA | −1.01 (−2.50, 0.50) |
| PFNA | −1.10 (−2.48, 0.30) |
| MeFOSAA | 1.09 (−0.08, 2.26)* |
| Testosterone | |
| n-PFOS | 2.43 (−1.40, 6.42) |
| PFNA | 1.70 (−1.50, 5.00) |
| MeFOSAA | −1.67 (−4.12, 0.84) |
| EtFOSAA | −1.88 (−3.92, 0.22)* |
| SHBG | |
| MeFOSAA | 0.0001 (−2.22, 2.27) |
All models were adjusted for age (time-varying), race/ethnicity, site, smoking status, parity, menopausal status (time-varying), and BMI (time-varying). *P <0.10; **P < 0.05.
Abbreviations: E2, estradiol; EtFOSAA, 2-(N-ethyl-perfluorooctane sulfonamido) acetate; FSH, follicle-stimulating hormone; MeFOSAA, 2-(N-methyl-perfluorooctane sulfonamido) acetate; n-PFOA, linear perfluorooctanoate; n-PFOS, linear perfluorooctane sulfonate; PFAS, per- and polyfluoroalkyl substances; PFNA, perfluorononanoate; SHBG, sex hormone-binding globulin.