Table 2.
Methylation patterns
| Cohort | NESP methylation mean ± SD (%) | XL methylation mean ± SD (%) | Exon A/B methylation mean ± SD (%) | Pattern |
|---|---|---|---|---|
| Group 1 (N = 31) | 40 ± 3 | 42 ± 3 | 54 ± 7 | NNN |
| Healthy (N = 11) | 41 ± 3 | 41 ± 3 | 52 ± 8 | NNN |
| PHP1a (N = 3) | 39 ± 2 | 42 ± 5 | 53 ± 3 | NNN |
| Unaffected family members/obligate carriers (N = 17) | 40 ± 3 | 42 ± 3 | 54 ± 5 | NNN |
| Group 2 (N = 21) | 41 ± 4 | 42 ± 5 | 3 ± 2a | NNL |
| Group 3 (N = 6) | 83 ± 8a | 36 ± 6 | 8 ± 5a | HNL |
| 3A (familial, N = 3) | 85 ± 4 | 39 ± 6 | 6 ± 0.4 | |
| 3B (sporadic, N = 3) | 81 ± 12 | 33 ± 6 | 9 ± 7 | |
| Group 4 (N = 21) | 85 ± 4a | 7 ± 4a | 4 ± 4a | HLL |
| Group 5 (N = 5) | 70 ± 5a,b | 20 ± 4a,b | 28 ± 7a,b | HMM |
a Significantly (P < 0.01) different from corresponding group 1 value, by Dunnett.
b Significantly (P < 0.001) different from corresponding group 4 value, by Tukey-Kramer.