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. 2021 Oct 18;40(50):6748–6758. doi: 10.1038/s41388-021-02054-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A UMAPs based on the top 20 principal components of all epithelial single-cell transcriptomes color-coded by tissue type, cell type and patient, and quantification of epithelial cell types per tissue type, AT1, alveolar type 1 cells, AT2, alveolar type 2 cells. B Average gene expression of selected marker genes for normal epithelial cell types. C Differentially expressed genes in tumor epithelial cells grouped by patients, maximum top ten genes showed per patient, for patient color code see (A). D Immunohistochemical staining of proteins encoded by selected differentially expressed genes indicated by black arrowheads in (C). E Mean pathway activity scores of tumor epithelial cells grouped by patient. F Distribution of histological subtypes, (G) mean module scores of normal epithelial cell type gene signatures, and (H) mean pathway activity scores of tumor epithelial cells sorted along principal component 1 (PC1). F, G, H Principal component analysis based on gene expression of all tumor epithelial single-cell transcriptomes; schematic depiction of tumor cell signature module scores along PC1.