Figure 5.

Pattern matching of the microbial PC1 values with the clinical and pathological scores of EAE at the three anatomical sites: feces, ileal contents, and the ileal mucosa. (A–I) We harvested samples from the three CMG-treated (Induction, blue circle; Latent, red triangle; and Whole, green square) and control groups (Control, black circle). The microbial PC1 values of ileal contents and the ileal mucosa, but not feces, significantly correlated with the EAE scores (A, D, G), perivascular cuffing (i.e., inflammation) scores (B, E, H), and demyelination scores (C, F, I) (P < 0.01).