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. 2021 Dec 3;12:760737. doi: 10.3389/fimmu.2021.760737

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Copyright © 2021 Yan, Cui, Fu, Su, Chen, Gu and Lin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network map of comparisons based on five treatments in grade 1-5 adverse events (A) and grade 1-5 immune-related adverse events (B). Each circular node represents a type of treatment. The node size is proportional to the total number of patients administering a treatment (in parentheses). Each line represents a type of head-to-head comparison. The width of lines is proportional to the total number of studies comparing the connected treatments. ICI, immune checkpoint inhibitor; n, number.