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. 2021 Dec 3;12:760737. doi: 10.3389/fimmu.2021.760737

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Copyright © 2021 Yan, Cui, Fu, Su, Chen, Gu and Lin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Safety profiles based on specific organs: pruritus (A), rash (B), severe skin reaction (C), myocarditis (D), nephritis (E), hepatitis (F), myositis (G), hypersensitivity/infusion reaction (H). Pooled incidences and 95% confidence intervals of grade 1–5 events for each treatment are at bottom and that of grade 3–5 events are at top of the figure. Each cell of the safety profiles contains the pooled relative risks and 95% confidence intervals for grade 1–5 (light gray cell) and grade 3–5 (dark gray cell) events; significant results are in bold. The pooled relative risks and 95% confidence intervals indicate the results of the top treatment compared with the bottom treatment. ICI, immune checkpoint inhibitor; n, number.