Table 2.
Association between albumin infusion and clinical outcomes in patients with septic shock and acute kidney injury.
| Outcomes | Non-albumin | Albumin | P-value | HR (95%CI) |
|---|---|---|---|---|
| Pre-matched cohort | n = 1970 | n = 891 | ||
| Primary outcome | ||||
| 28-day mortality, n (%)a | 533 (27.1) | 231 (25.9) | 0.002 | 0.75 (0.63–0.90) |
| Secondary outcomes | ||||
| 90-day mortality, n (%)a | 684 (34.7) | 333 (37.4) | 0.24 | 0.92 (0.79–1.06) |
| Recovery of renal function, n (%)b | 1291 (65.5) | 514 (57.7) | 0.004 | 0.78 (0.66–0.92) |
| Length of hospital stay (days, median [IQR])c | 12.8 [8, 20] | 18.3 [11, 29] | < 0.001 | |
| Length of ICU stay (days, median [IQR])c | 5.9 [3.4, 11.2] | 8.8 [4.2, 16.8] | < 0.001 | |
| Post-matched cohort | n = 749 | n = 749 | ||
| Primary outcome | ||||
| 28-day mortality, n (%)a | 224 (29.9) | 184 (24.6) | 0.002 | 0.72 (0.59–0.86) |
| Secondary outcomes | ||||
| 90-day mortality, n (%)a | 268 (35.8) | 275 (36.7) | 0.474 | 0.94 (0.79–1.12) |
| Recovery of renal function, n (%)b | 487 (65.0) | 446 (59.5) | 0.345 | 0.82 (0.69–1.11) |
| Length of hospital stay (days, median [IQR])c | 13.45 [8.1, 20.2] | 18 [10.8, 28.4] | < 0.001 | |
| Length of ICU stay (days, median [IQR])c | 6.4 [3.7, 12.8] | 8.2 [4.2, 16.3] | 0.001 | |
IQR interquartile range, ICU intensive care unit, HR hazard ratio, CI confidence interval.
aCox proportional hazard models were used to assess the impact of albumin infusion on mortality outcomes adjusting for confounders selected from P-value < 0.05 in univariate analysis.
bRecovery of renal function was defined as being discharged from ICU with serum creatinine below 1.5 times the baseline value and normal urine output (> 0.5 ml/kg/h). Impact of albumin infusion on the recovery of renal function was assessed using the logistic regression model adjusting for age, SAPSII score, and RRT use.
cWilcoxon rank sum test was used to assess the association between albumin infusion and length of stay.