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. 2021 Dec 2;12:774916. doi: 10.3389/fgene.2021.774916

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Copyright © 2021 Douillard, Castelli, Mack, Hollenbach, Gourraud, Vince and Limou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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History and development of HLA nomenclature as illustrated by HLA-A*02:01:01:134Q. Each level of resolution corresponds to a group of HLA alleles fitting the description, except for the full DNA sequence, a unique HLA allele. Colored pins represent non-synonymous polymorphism (pink) and synonymous or intronic polymorphisms (purple); the displayed polymorphism is only indicative and does not reflect HLA-A*02:01:01:134Q sequence. P and G groups are named with the lowest numbered two-field (HLA-A*02:01) and three-field (HLA-A*02:01:01) HLA allele name, respectively. Class II P and G groups are based on exon 2 only, while class I P and G groups are based on exons 2 and 3. Supertypes are not defined as part of the official nomenclature (Wang and Claesson, 2014; del Guercio et al., 1995; Sidney et al., 1995). Created with biorender.com.