Table 1.
PANX3 tissue distribution and cellular localization
| Tissue | Location/cell types | Localization |
|---|---|---|
| Blood Vessels [22] | Alveoli | Peri-nuclear |
| Juxtaglomerular apparatus | Punctate staining throughout | |
| Endothelium of cortical arterioles, first-order pulmonary artery | ||
| Endothelium and smooth muscle cells of small coronary arteries (luminal diameter < 100 µM), pulmonary arteries of the distal lung | ||
| Male Reproductive Tract [21] | Testis, efferent ducts, epididymis | |
| Leydig cells (testis) | ||
| Ciliated cells (efferent ducts) | Throughout | |
| Non-ciliated cells (efferent ducts) | Lateral plasma membrane and basal region | |
| Principal cells (epididymis) | Apical membrane | |
| Lactating Mammary Gland [20] | ||
| Bone [2, 14, 26, 28] | Osteoblasts and osteoprogenitor cells | Intracellular, cell surface |
| Osteocytes | ||
| Cartilage [3, 16, 20] | Pre-hypertrophic chondrocytes | |
| Hypertrophic chondrocytes | Intracellular, cell surface | |
| Intervertebral Discs [18, 19] | Annulus Fibrosus | |
| Nucleus Pulposus | ||
| Teeth [13, 29–31] | Human dental pulp cells | |
| Human odontoblast-like cells | Cytosolic, cell surface | |
| Mouse P1 molars (dental mesenchyme) and incisors | ||
| Early and late pre-secretory stages of mouse preodontoblasts | Cell surface | |
| Ear [24, 25] | Cochlear bone and modiolus of inner ear | |
| Cochlea | ||
| Skin [4, 9, 32–34] | All layers of the epidermis (keratinocytes) | Intracellular |
| Juvenile thin and thick skin, but not newborn mouse dorsal skin; E13.5 dorsal skin | ||
| Sebaceous glands, blood vessels, eccrine glands | Intracellular | |
| Human dermal fibroblasts | ||
| Vomeronasal Organ (VNO) [23] | Autonomous sensory nerve, basal and ciliated epithelium of the non-sensory epithelium and cartilaginous section of the VNO in juvenile mice | |
| Small Intestine [20] | Epithelium | |
| Skeletal Muscle [4, 15, 35] | Adult skeletal muscle tissue, absent in human fetal tissue | Diffuse staining throughout muscle fibres, striations |
| Human skeletal muscle satellite cells | ||
| Embryonic to adult mouse skeletal muscle, more abundant in fast-twitch than slow-twitch muscles | Punctate structures throughout myofibers and cell surface | |
| Rat skeletal muscle |