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Overview of TIER1 genes and their respective roles in platelet formation and function, and the coagulation cascade. Top: identified TIER1 genes with a role in platelet formation and function, ordered by the molecular pathway in which they function. Bottom: TIER1 genes related to the coagulation cascade, coagulation inhibition, production of coagulation factors, and fibrinolysis. vWF, von Willebrand factor. Figure created with Biorender.com
