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. 2021 Dec 3;11:780118. doi: 10.3389/fonc.2021.780118

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Copyright © 2021 Zhong, Tan, Pan, Jiang, Zhou, Lai, Chen, Fan, Deng, Xu and Zha

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of chidamide on tumor growth in xenograft mouse models. (A) Cell injection protocol in a FL tumor xenograft model. Tumor volumes (B) and body weights (C) of mice were measured daily and presented as mean ± S.D. (D) Images of tumors from DOHH2-bearing xenograft mice after the indicated treatments (n=10). Tumor volumes (E) and weights (F) in the control and chidamide groups were compared to evaluate the treatment response to chidamide. (G) Kaplan Meier overall survival (OS) curves of tumor-bearing xenograft mice. (H) Chidamide suppressed the PDK1-Akt-P27-CDK2 signaling pathway in vivo. The protein levels of PDK1, AKT, P27, CDK2, PARP, cleaved-PARP, caspase3 and cleaved-caspase-3 were determined by Western blot. (**p < 0.01; ***p < 0.001).