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. 2021 Dec 3;12:767314. doi: 10.3389/fendo.2021.767314

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Copyright © 2021 Albhaisi and Noureddin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inflammation associated with NASH. Inflammation is driven by the cellular interplay involving hepatocytes, hepatic stellate cells and recruited immune cells. Hepatocyte death and inflammatory mediators are key contributors to inflammation in NAFLD and NASH progression. ILC, innate lymphoid cells; LSECs, liver sinusoidal endothelial cells; MCP-1, macrophage chemotactic protein 1; MPO, myeloperoxidase.