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. 2021 Dec 3;8:784876. doi: 10.3389/fmolb.2021.784876

FIGURE 2.

FIGURE 2

Summary of the genomic findings of Case 1. Genes with mutations identified in each tumor entity of the inferior and superior left lung (I1/I2, I3, and S1) are listed as symbol and aminoacidic changes (% mutant allele fraction). The Venn diagram was used to show the shared mutations (red circle in I1/I2 nodule and green circle in I3 and S1 nodules) and exclusive mutations for each tumor fraction. The different numbers represent the somatic mutations in the corresponding samples, whereas the number in the overlapped regions red (I1/I2) and green (I3 and S1) are ubiquitous somatic mutations shared by the two concurrent tumor components (I1/I2) and by the two isolated adenocarcinoma nodules (I3 and S1) in the same patient. I1/I2, mixedcarcinoid/adenocarcinoma tumor; I3, inferior adenocarcinoma tumor, S1, superior adenocarcinoma tumor. Asterisks (*) indicate the different mutation in the same gene. LL, Left lung; RL, right lung. AC, atypical carcinoid; PA, pulmonary adenocarcinoma.