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. 2021 Dec 3;8:784876. doi: 10.3389/fmolb.2021.784876

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Copyright © 2021 Parente, Rossi, Sparaneo, Fabrizio, Centonza, Taurchini, Mazza, Cassano, Miscio, Centra, Ferretti, Di Micco, Graziano and Muscarella.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Case 2, lymph node metastasis. Lymph node showing adenocarcinoma component intermingled with carcinoid; hematoxylin/eosin, 3.5× (A). Immunostaining showing diffuse and strong immunoreactivity for Synaptofisin only in the carcinoid component (on the left, 3.5×; B). At higher power field, composite neoplasm (hematoxylin/eosin, C, 4×) showing diffuse and strong immunoreactivity for CK7 only in the adenocarcinomatous (D, 4×) and chromogranin only in the neuroendocrine component (E, 4×), respectively.