TABLE 2.
Molecular profile of published combined pulmonary adenocarcinoma and atypical carcinoids of lung primary site of neoplasms.
| Reference | Mutated genes | Type of mutation (aa change) | |||
|---|---|---|---|---|---|
| NE (AC) component | NSCLC (PA) component | NE (AC) component | NSCLC (PA) component | ||
| Olofson et al. Olofson and Tafe (2018) | BRAF | BRAF | p.Val600Glu | p.Val600Glu | |
| La Rosa et al. La Rosa et al. (2018) | KRAS | KRAS PAPPA2 NF1 SMARCA4 | p.Gly13Asp p.Arg901Leu p.Val2106Phe | p.Gly13Asp p.Arg901Leu p.Val2106Phe p.Pro171Leu | |
| PAPPA2 | |||||
| NF1 | |||||
| Present work | BRAF | BRAF , NF1 , NF1 , STK11 , AKT2 | p.Gly466Ala, p.Pro1359LeufsTer19, p.Glu1928Ter, p.Gly188AlafsTer99, p.Leu52Ter, p.Arg806Ter, p.Thr107Ser, p.Arg1135Gln | p.Gly466Ala, p.Pro1359LeufsTer19, p.Glu1928Ter, p.Gly188AlafsTer99, p.Leu52Ter | Case 1 |
| NF1 | |||||
| NF1 | |||||
| STK11 | |||||
| AKT2 | |||||
| DDR2 | |||||
| CDK6 | |||||
| SMARCA4 | |||||
| Present work | NF1 | NF1 , PTEN, NOTCH1 | p.Gln28Ter, p.Arg1325Thr, p.Arg44Leu | p.Gln28Ter, p.Thr319Ter, p.Pro498Arg | Case 2 |
| NF1 | |||||
| CDK12 | |||||
AC, atypical carcinoid; PA, pulmonary adenocarcinoma; m, months; NE, neuroendocrine; NSCLC, non-small cell lung cancer; aa change, aminoacidic change.
Shared gene mutations are highlighted in bold.