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. 2021 Dec 3;9:759237. doi: 10.3389/fcell.2021.759237

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Copyright © 2021 Mbadhi, Tang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The myogenic regulatory factors (MRFs) pathway during skeletal muscle development and regeneration. Satellite stem cells remain in a quiescent state until activation upon muscle injury. Quiescent satellite stem cells expressing Pax7 are activated to committed progenitor cells expressing Myf5. However, a portion of the cells undergoesself-renewal to regenerate the stem cell pool. Proliferating myoblasts express Myf5 and MyoD while Pax7 is downregulated. MyoD is the master regulator of myoblast differentiation that initiates proliferating myoblast cells to exit the cell cycle. Differentiation and fusion precede to form myofibers under the regulation of MyoG and Mrf4.