KEY RESOURCES TABLE

REAGENT OR RESOURCE	SOURCE	IDENTIFIER
Chemicals
FK866	Selleck Chemicals	Catalog No. S2799; CAS No. 658084–64–1
LPS (E. coli 055:B5, L-2880)	Sigma–Aldrich	L2880; CAS No. 93572–42–0
[U-13C]TRP	Cambridge Isotope Laboratories	Cat. #CLM-4290-H-PK
[2,4,5,6-2H]NAM	Cambridge Isotope Laboratories	Cat. #DLM-6883-PK; CAS 347841–88–7
Experimental Models: Organisms/Strains
C57BL/6J.Nia (Catheter implanted in the right jugular vein)	National Institute on Aging Rodent Colony	N/A
40% caloric restricted C57BL/6J.Nia mice(Catheter implanted in the right jugular vein)	National Institute on Aging Rodent Colony	N/A
Software and Algorithms
MAVEN software	http://genomics-pubs.princeton.edu/mzroll/index.php	N/A
Metabolic flux analysis	https://github.com/XiaoyangSu/NAD-fluxes	N/A
Metabolomics and isotope tracing raw dataset	https://massive.ucsd.edu/ProteoSAFE/dataset.jsp?accession=MSV000087933	MSV000087933