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SARS-CoV-2 infection, with age-, sex-, and race/ethnicity-dependent moderators that influence severity, initiates interdependent damage pathways that have the potential to cascade toward the outcome consequence of long-term cognitive decline and/or dementia. Lighter gray arrows represent conditional influences. SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; PTSD, posttraumatic stress disorder; COVID-19, coronavirus disease 2019.
