Skip to main content
. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: J Biomed Mater Res A. 2021 Jul 29;110(2):245–256. doi: 10.1002/jbm.a.37280

Figure 1. Cellular reactions to GF-BP, ePC-UPy, UBM-ECM, and PP.

Figure 1.

(A) GF-BP, ePC-UPy, UBM-ECM, and PP at days 2, 21, and 180. (B) Quantification of total nuclei per mm2 of material. With GF-BP, there was an early and robust cellular response, noted at 2 days post implantation with mononuclear cells limited to the edges of the implant at the interface with native tissue. There was a marked reduction in number of cells within GF-BP at 180 days. In contrast, beginning early following implantation and continuing throughout the study duration, mononuclear cells and occasional multinucleated giant cells were diffusely distributed throughout the thickness of the ePC-UPy material. UBM-ECM showed a brisk mononuclear cell infiltration noted at 2 days post implantation and continuing through days 14-21 with disappearance of inflammation following degradation and replacement by fibrous tissue. Fibers of the PP mesh became rapidly surrounded by a variably thick cell layer of mononuclear and multinucleated giant cells that became thinner but persisted throughout the 180 days of the study. Arrows define the interface of the material with surrounding tissue, asterisks show PP fibers. All H&E stained, scale bars 200μm.