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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Med Sci Sports Exerc. 2022 Jan 1;54(1):77–88. doi: 10.1249/MSS.0000000000002772

Figure 4: Effect of Tumor Size and Growth on Whole Body Metabolism.

Figure 4:

Data is expressed as mean (SEM). A. Study Design. B. Tumor Volume over the course of the study in mice placed in the CLAMs Unit. Grey bar indicates when mice were placed in the CLAMs Unit. N=16. C. Average carbohydrate oxidation in grams per minute per light and dark cycle. N:11-16 per group. D. Average lipid oxidation in grams per minute per light and dark cycle. N:11-16 per group. E. Average daily lipid oxidation correlated to tumor mass. F. Average daily lipid oxidation correlated to tumor growth rate. G. Average daily lipid oxidation correlated to hindlimb muscle mass. H. Average daily lipid oxidation correlated to plasma IL-6. Abbreviations: ME: Main effect, pg/mL: picograms per milliliter, mg: milligrams, g: grams, PBS: phosphate buffered saline, LLC: Lewis Lung Carcinoma, cm3: centimeters cubed, g/min: grams per minute. One-way repeated measures ANOVA was used to compare tumor volume over time (Figure B). Different letters mean different between groups. Two-way repeated measures ANOVA (2-time points x 2 treatments) was used to compare fuel oxidation during the light and dark cycle. (Figures C, D). Pearson Correlation Coefficient was used for correlations (Figure E-H). Statistical significance was set a p<0.05.