Table 1:
Effect of LLC on Animal Characteristics
| Treatment | PBS | LLC |
|---|---|---|
| N | 24 | 33 |
| Tumor Inoculation Age (wks.) | 11.8 (0.1) | 11.5 (0.1) |
| Study Duration (days) | 26.4 (0.3) | 26.1 (0.3) |
| End of Study Age (wks.) | 15.6 (0.1) | 15.2 (0.1) |
| BW Pre Tumor Inoculation (g) | 24.9 (0.5) | 24.8 (0.4) |
| BW Day 10 of Study (g) | 26.2 (0.4) | 25.8 (0.4) |
| BW End of Study (g) | 26.7 (0.4) | 27.1 (0.3) |
| Tumor Mass (g) | - | 2.7 (0.5) |
| BW End of Study – Tumor Mass (g) | 26.7 (0.4) ^ | 24.4 (0.5) * |
| Tumor Growth Rate 15-25days (cm3/5 days) | - | 0.197 (0.017) |
| Gastrocnemius Mass (mg) | 115 (2) | 108 (3) * |
| TA Mass (mg) | 41 (1) | 37 (1) * |
| Soleus Mass (mg) | 7.4 (0.3) | 6.8 (0.2) |
| EDL Mass (mg) | 9.7 (0.3) | 9.1 (0.2) |
| Testes Mass (mg) | 198 (3) | 202 (4) |
| Heart Mass (mg) | 156 (6) | 143 (4) |
| Tibia (mm) | 16. 7 (0.1) | 16.5 (0.1) |
Data is expressed as mean (SEM). Abbreviations: PBS: Phosphate Buffered Saline, LLC: Lewis Lung Carcinoma, wks.: weeks, BW: body weight, g: grams, mg: milligrams, eWAT: epididymal white adipose tissue, and mm: millimeter, cm3/5 day: centimeters cubed per 5 days, pg/mL: picograms per milliliter, N.D.: Not detected, IL-6: Interleukin-6. Body weight change (Δ)is the following calculation (body weight end of study – tumor mass)/body weight day 10 in percent. Tumor growth rate is calculated as the tumor volume slope from days 15 to 25. Unpaired t-test was used to compare PBS to LLC.
*
Different than PBS.
^
different than pre tumor inoculation. Statistical significance was set a p<0.05.