Table 2:
Effect of LLC on Daily Average Indirect Calorimetry, Physical Activity, and Fuel Oxidation
| PBS | LLC | |
|---|---|---|
| N | 11 | 16 |
| Time since Tumor Inoculation (wks.) | 2.2 | 2.2 |
| Tumor Volume Pre-CLAMs (cm3) | - | 0.56 (0.01) |
| Tumor Volume Post CLAMs (cm3) | - | 1.61 (0.18) |
| Body Weight | ||
| Body Weight Pre-CLAMs (g) | 26.0 (0.6) | 27.2 (0.5) |
| Body Weight Post-CLAMs (g) | 25.3 (0.6) | 26.4 (0.6) |
| BW Change during CLAMs (%) | −2.8 (0.7) | −2.6 (1.0) |
| Body Composition Pre | ||
| Lean Mass (g) | 23.0 (0.6) | 24.1 (0.5) |
| Fat Mass (g) | 2.4 (0.2) | 2.4 (0.1) |
| Metabolic Parameters: Daily Average | ||
| Relative VO2 (ml/kg lean mass/hr) | 3977 (225) | 4063 (166) |
| Absolute VO2 (ml/hr) | 91.5 (5.3) | 97.6 (3.7) |
| Relative VCO2 (ml/kg lean mass/hr) | 3443 (191) | 3456 (150) |
| Absolute VCO2 (ml/hr) | 79.0 (4.7) | 83.0 (3.4) |
| Respiratory Exchange Ratio | 0.860 (0.005) | 0.847 (0.008) |
| Lipid Oxidation (g/min) | 0.338 (0.028) | 0.397 (0.024) |
| Carbohydrate Oxidation (g/min) | 1.13 (0.08) | 1.102 (0.075) |
| Energy Expenditure (kcal/kg lean mass/hr) | 19.4 (1.1) | 19.7 (0.8) |
| Heat Production (watts) | 0.44 (0.03) | 0.48 (0.02) |
| Food Intake (grams) | 3.89 (0.23) | 3.91 (0.47) |
| Cage Activity (counts) | 11392 (866) | 8713 (100) * |
Data is expressed as mean (SEM). Metabolic Parameters are presented as the daily average. Abbreviations: PBS: Phosphate Buffered Saline, LLC: Lewis Lung Carcinoma, wks.: weeks, BW: body weight, g: grams, cm3: centimeters cubed, ml/kg lean mass/hr: milligrams per kilogram of lean mass per hour, g/min: grams per minute, VO2: Oxygen consumption, VCO2: Carbon Dioxide CLAMs: Comprehensive Laboratory Animal Monitoring System. Food intake was the average of food consumed over 5 days. Unpaired t-test was used to compare PBS to LLC.
*
Different than PBS. Statistical significance was set a p<0.05.