. Author manuscript; available in PMC: 2023 Jan 1.

Published in final edited form as: Med Sci Sports Exerc. 2022 Jan 1;54(1):77–88. doi: 10.1249/MSS.0000000000002772

Table 3:

Relationship of Tumor Growth and Indices of Cachexia on Physical Activity, Indirect Calorimetry and Fuel Utilization in LLC Mice.

Indices of Cachexia
	Activity	RER	EE	VCO2	VO2	Lipid Oxidation	CHO Oxidation
Tumor Mass
*Average Daily*	Figure 5B	−0.348	0.157	0.151	0.223	0.335	−0.074
*Dark Cycle*	−0.371	−0.259	0.200	0.208	0.279	0.286	−0.191
*Light Cycle*	−0.700 ^*	−0.332	0.084	0.089	0.146	0.187	−0.288
BWΔ d10
*Average Daily*	0.410	0.471	−0.191	−0.202	−0.301	−0.464	0.125
*Dark Cycle*	0.320	0.383	−0.199	−0.228	−0.331	−0.421	0.221
*Light Cycle*	0.520 ^*	0.503	−0.168	−0.168	−0.251	−0.329	0.330
Hindlimb Muscle Mass
*Average Daily*	Figure 5D	0.823 ^*	−0.041	−0.082	−0.254	−0.791 ^*	0.451
*Dark Cycle*	0.590 ^*	0.827 ^*	0.012	−0.025	−0.215	−0.856 ^*	0.461
*Light Cycle*	0.615 ^*	0.684 ^*	−0.116	−0.173	−0.289	−0.484	0.409
eWAT
*Average Daily*	0.620 ^*	0.521 ^*	−0.011	−0.064	−0.177	−0.515 ^*	0.338
*Dark Cycle*	0.598 ^*	0.604 ^*	0.066	0.023	−0.111	−0.596 ^*	0.282
*Light Cycle*	0.592 ^*	0.272	−0.125	−0.198	−0.244	−0.249	0.091
Plasma IL-6
*Average Daily*	Figure 5E	−0.560 ^*	0.080	−0.205	−0.028	0.451	−0.202
*Dark Cycle*	−0.457	−0.633 ^*	0.116	−0.262	−0.071	0.617 ^*	−0.160
*Light Cycle*	−0.548 ^*	−0.273	0.003	−0.101	0.024	0.203	−0.167

Data is expressed as r correlation value. Abbreviations: eWAT: epididymal white adipose tissue, BWΔ d10: Body weight change is the (body weight end of study – tumor mass)/body weight day 10 in percent, RER: respiratory exchange ratio, EE: Energy expenditure, VO2: Oxygen consumption, VCO2: Carbon Dioxide, CHO: carbohydrate. Pearson Correlation Coefficient was used for correlations.

And bolded indicate variables are significantly correlated. Correlations trending to be significant p<0.100 are italicized. Statistical significance was set a p<0.05. N=15.