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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Clin Pharmacol Ther. 2021 Sep 20;111(1):243–251. doi: 10.1002/cpt.2400

Figure 1. Study design diagram.

Figure 1.

a. As-started: treatment classification as the first drug exposure for the pre-specified duration

b. Non-PPI/H2RA users were 1:1 matched to PPI users by random sampling from the patient pool who met other inclusion/exclusion criteria.

c. Up to 31-day gaps in medical or pharmacy enrollment allowed

d. Earliest of outcome of interest, death, disenrollment, 365 days of follow-up, end of the study period

EHR = electronic health records

PPI = Proton pump inhibitor

H2RA = Histamine type-2 receptor antagonists