Table 2:

Immunohistochemical analyses of HKDC1 protein expression

System	Organ/Tissue	Comments	Reference
Gastrointestinal	Colon	Strong HKDC1 expression restricted to the epithelial cells of the villi	[13]
	Liver	Diffuse, low level expression in hepatocytes
Genitourinary	Kidney	HKDC1 expression predominately in the renal tubules	[13]
Cardiovascular	Heart	Weak intensity* staining in cardiomyocytes	[14]
Endocrine	Thyroid	Moderate to strong intensity staining in the follicular epithelium	[14]
Gastrointestinal	Esophagus	Moderate intensity staining in the suprabasal squamous epithelium	[14]
		Weak intensity staining in basal layer
	Stomach	Strong intensity staining in parietal and chief cells	[14]
		Moderate intensity staining in the superficial foveolar epithelium
	Small intestine	Strong intensity staining in the villous brush border	[14]
	Colon	Strong intensity staining in the surface epithelium	[14]
		Weak intensity staining in the crypt base epithelium
	Liver	Weak intensity staining in the interlobular bile duct	[14]
	Pancreas**	Strong intensity staining in the larger and interlobular pancreatic ducts, acinar centrocytes	[14]
Genitourinary	Kidney	Mostly weak intensity staining in the renal tubule and glomerulus	[14]
	Prostate	Moderate intensity staining in basal cells	[14]
		Weak to moderate intensity staining in stromal cells
		Weak intensity staining in the gland epithelium
	Testes	Weak intensity staining in spermatocytes	[14]
Integumentary	Skin	Moderate intensity staining in the sweat gland duct	[14]
		Weak intensity staining in the epidermis, hair follicle, and sweat gland
Lymphatic	Spleen	Weak to moderate intensity staining in white pulp	[14]
		Weak intensity staining in red pulp
Pulmonary	Lung	Strong intensity staining in alveolar macrophages	[14]
		Moderate intensity staining in the bronchial epithelium
		Weak intensity staining in alveolar lining cells

^*HKDC1 immunostaining assessed by estimating the intensity of cytoplasmic staining and assigning it to one of four categories: no staining, weak-positive, moderate-positive, or strong positive staining

^**In the pancreas, the most intense HKDC1 staining was seen in exocrine tissue; pancreatic islet cells of the endocrine system exhibited weak intensity staining