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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Acta Paediatr. 2021 Oct 28;111(1):54–58. doi: 10.1111/apa.16147

Table 1.

Summary of B. infantis impact on host immune function

Cells/Tissue type Effect of B. infantis Reference
Immature intestinal tissue

  • Decreased IL-8 and IL-6 production

  • Decreased TLR 2 and TLR4 mRNA expression

 17
Intestinal epithelial cells (Caco-2)

  • Increased IL-10 mRNA expression

 17
Dendritic Cells

  • Increased production of IL-10 compared to IL-12p70

  • Promotes a regulatory DC phenotype leading to increased regulatory T cells

 22
Gut (colonization)

  • Increased levels of salivary secretory IgA

  • Increased memory B cells

  • Regulatory/anti-inflammatory immune profile

  • Decreased fecal pro-inflammatory cytokines

  • Increased fecal lactate and acetate

 13, 21, 23, 24, 27