Table 1:
Baseline patient characteristics of AF patients prescribed a DOAC stratified by the presence of co-prescribed medications with potential interaction.
| Characteristic | Total (N=8576) | Interacting Medication | P-value | |
|---|---|---|---|---|
| Yes (N=2610) | No (N=5966) | |||
| Age (years) | 69.5 (11.9) | 68.4 (11.8) | 70.0 (11.9) | <0.001 |
| Women | 3008 (35.1%) | 1072 (41.1%) | 1936 (32.5%) | <0.001 |
| White | 8094 (94.4%) | 2486 (95.2%) | 5608 (94.0%) | 0.23 |
| Body-mass index (kg/m2) | 30.4 (6.8) | 31.1 (7.3) | 30.1 (6.6) | <0.001 |
| CHA2DS2-VASc score | 3 (2 – 4) | 3 (2 – 4) | 3 (2 – 4) | 0.51 |
| ATRIA bleeding risk score | 2 (1 – 4) | 2 (1 – 4) | 2 (1 – 3) | 0.78 |
| Charlson co-morbidity index | 2 (1 – 4) | 2 (1 – 4) | 2 (1 – 4) | 0.49 |
| Diabetes mellitus | 2091 (24.4%) | 671 (25.7%) | 1420 (23.8%) | 0.06 |
| Hypertension | 5811 (67.8%) | 1799 (68.9%) | 4012 (67.2%) | 0.13 |
| Hyperlipidemia* | 4633 (54.0%) | 1387 (53.1%) | 3246 (54.4%) | 0.28 |
| Heart failure | 2801 (32.7%) | 942 (36.1%) | 1859 (31.2%) | <0.001 |
| Myocardial infarction | 1026 (12.0%) | 290 (11.1%) | 736 (12.3%) | 0.11 |
| Peripheral vascular disease | 787 (9.2%) | 220 (8.4%) | 567 (9.5%) | 0.11 |
| Aortic atherosclerotic disease | 751 (8.8%) | 181 (6.9%) | 570 (9.6%) | <0.001 |
| Bio-prosthetic valve | 423 (4.9%) | 112 (4.3%) | 311 (5.2%) | 0.07 |
| Anemia | 1051 (12.3%) | 300 (11.5%) | 751 (12.6%) | 0.16 |
| Serum Creatinine (mg/dl) | 1.1 (0.4) | 1.1 (0.5) | 1.1 (0.4) | 0.10 |
| Glomerular filtration rate (ml/minute)** | 84.8 (38.1) | 86.5 (41.3) | 84.0 (36.6) | 0.10 |
| Type of DOAC | <0.001 | |||
| Apixaban | 3312 (38.6%) | 968 (37.1%) | 2344 (39.3%) | |
| Dabigatran | 2198 (25.6%) | 768 (29.4%) | 1430 (24.0%) | |
| Rivaroxaban | 3066 (35.8%) | 874 (33.5%) | 2192 (36.7%) | |
| Off-label DOAC dose | <0.001 | |||
| Low DOAC dose | 1071 (12.5%) | 392 (15.0%) | 679 (11.4%) | |
| High DOAC dose | 202 (2.4%) | 70 (2.7%) | 132 (2.2%) | |
*
Hyperlipidemia was identified using International Classification of Diseases 9 (272.0–272.4, 374.51) and 10 (E78, H02.61–66) diagnostic codes.
**
Estimated using the Cockroft Gault method.