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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Am J Cardiol. 2021 Oct 27;162:80–85. doi: 10.1016/j.amjcard.2021.09.025

Table 5.

Multivariable analysis of predictors of major bleeding

Variable Hazard ratio (95% confidence interval) P-value
Age 1.03 (1.00 – 1.06) 0.03
Female 0.87 (0.60 – 1.27) 0.47
Body mass index 1.02 (0.99 – 1.05) 0.19
Apixaban (reference)
Dabigatran 0.88 (0.53 – 1.45) 0.61
Rivaroxaban 1.51 (1.02 – 2.22) 0.04
Off-label low dose of DOAC 1.03 (0.62 – 1.73) 0.90
CHA2DS2-VASc score 1.20 (1.06 – 1.36) 0.004
Interacting medication 0.53 (0.34 – 0.83) 0.006
Serum sodium 0.97 (0.92 – 1.01) 0.1538
Creatinine clearance 0.99 (0.99 – 1.00) 0.1904