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. Author manuscript; available in PMC: 2022 Jun 15.
Published in final edited form as: Clin Cancer Res. 2021 Sep 30;27(24):6800–6814. doi: 10.1158/1078-0432.CCR-21-0374

Figure 5.

Figure 5.

Proteomics alterations induced by THIO. (A-C) The heatmap of the top 25 significantly changed proteins in M059K, LN229 and U87MG cells. Cells were treated with or without THIO at 5 μM for 72 hours and then profiled by the RPPA assay. (D-F) The heatmap of common proteins regulated by THIO in M059K (D), LN229 (E) and U87MG (F) cells. (G-J) Western blot was performed to confirm the change of these proteins in M059K (more sensitive to THIO) (G), LN229 (less sensitive to THIO) (H), and DBTRG-05MG (more resistant to THIO) (I), and a neurosphere TS-603 (J) after treatment with THIO at 5 μM. Actin serves as a loading control. (K-N) fGSEA plots of SIGNALING BY PDGF pathway in M059K, H4, D2224MG and DBTRG-05MG cells.