Table 3.
Correlation between gene association P-values computed by MAGENTA and MAGMA for top five gene sets.
| Population, GWAS, Gene Window Upstream/Downstream | Gene set database: Gene set Name | Gene set size | Pearson Correlation Coefficient | Pearson p-value | Spearman’ s Rank Correlation Coefficient | Spearman p-value |
|---|---|---|---|---|---|---|
| AA, PDR Analysis, 5kb/5kb | GO: REGULATION OF NITRIC OXIDE BIOSYNTHETIC PROCESS | 53 | 0.90 | 8.99 X 10−18 | 0.93 | 7.49 X 10−21 |
| AA, PDR Analysis, 5kb/5kb | GO: REGULATION OF LIPID CATABOLIC PROCESS | 52 | 0.86 | 4.78 X 10−16 | 0.86 | 3.03 X 10−16 |
| AA, Extremes of DR Analysis, 110kb/40kb | KEGG: APOPTOSIS | 88 | 0.95 | 4.25 X 10−42 | 0.96 | 5.01 X 10−44 |
| EU, PDR Analysis, 110kb/40kb | REACTOME: LIPID DIGESTION MOBILIZATION AND TRANSPORT | 46 | 0.86 | 6.28 X 10−14 | 0.86 | 6.23 X 10−14 |
| EU, PDR Analysis, 5kb/5kb | MGI: MP0008067 RETINAL GANGLION CELL DEGENERATION | 16 | 0.93 | 7.35 X 10−7 | 0.92 | 7.99 X 10−7 |
AA = African American, EU = European, PDR = Proliferative Diabetic Retinopathy, DR = Diabetic Retinopathy