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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: J Pept Sci. 2021 Nov 7;28(1):e3377. doi: 10.1002/psc.3377

Figure 4.

Figure 4.

(A) A scheme contrasting the different release rates of a positively charged protein as a function of the electrostatic charge of a gel network. Relative release profiles of α-lactalbumin (●), myoglobin (◼), and lactoferrin (▴) from negatively charged (B) and positively charged gels (C). Reproduced by permission of The Royal Society of Chemistry. (D)-(i) Positively charged STINGel binds with the negatively-charged thiophoshphate groups of CDN; (ii) antiparallel beta sheet nanofiber formed by the MDP peptide, (iii) SEM micrograph of the MDP gel and, (E) Drug release profile depicting the prolonged release of CDN from MDP (blue, closed circles) relative to the neutral collagen matrix (green, open circles). Reprinted from Biomaterials, 163, David G. Leach, Neeraja Dharmaraj, Stacey L. Piotrowski, Tania L. Lopez-Silva, Yu L. Lei, Andrew G. Sikora, Simon Young, Jeffrey D. Hartgerink, STINGel: Controlled release of a cyclic dinucleotide for enhanced cancer immunotherapy, Pages No., Copyright (2018), with permission from Elsevier.