Table 1.

Relationship between ITPR3, S100A4, EGFR and clinicopathological features in human cholangiocarcinoma cases.

	Cases	ITPR3		p	S100A4		p	EGFR		p
Clinical Features	n	Negative	Positive		Negative	Positive		Negative	Positive
Gender
Male	32	10	22		29	3		22	10
Female	25	5	20	0.339	23	2	0.856	17	8	0.952
Age (years)
≤60	27	5	22		24	3		17	10
>60	30	10	20	0.255	28	2	0.554	22	8	0.400
Smoking
Yes	18	3	15		16	2		13	5
No	37	10	27	0.396	34	3	0.716	24	13	0.585
Alcohol Use
Yes	16	4	12		15	1		12	4
No	41	11	30	0.888	37	4	0.674	27	14	0.504
CA 19-9
≤ 37 U/ml	12	7	5		12	0		9	3
> 37 U/ml	24	6	18	0.049	22	2	0.375	14	10	0.326
Localization
Intrahepatic	14	6	8		14	0		7	7
Extrahepatic	43	9	34	0.106	38	5	0.182	32	11	0.088
Histology
Papillary	15	4	11		14	1		10	5
Others	42	11	31	0.971	38	4	0.737	29	13	0.865
Angiovascular Invasion
Positive	42	10	32		37	5		28	14
Negative	15	5	10	0.472	15	0	0.162	11	4	0.634
Histological Grade
G1	14	2	12		14	0		12	2
G2	38	12	26		35	3		25	13
G3	5	1	4	0.429	3	2	0.024	2	3	0.140
Lymph node metastasis
Positive	23	2	21		18	5		15	8
Negative	28	10	18	0.024	28	0	0.009	20	8	0.634
T stage
T1 +T2	34	9	25		33	1		26	8
T3+ T4	23	6	17	0.974	19	4	0.058	13	10	0.112
TNM stage
I+II	31	9	22		30	1		25	6
III+IV	25	6	19	0.673	21	4	0.096	14	11	0.046
Surgical margin
Positive	22	8	14		18	4		15	7
Negative	35	7	28	0.172	34	1	0.047	24	11	0.975