Figure 8.

Applying MAGIC to schizophrenia patients from PHENOM. A) Cross-validation for choosing the “optimal” k. B) Voxel-wise effect size maps for the neuroanatomical patterns between the 2 subtypes and CN. C) Effect size maps for the neuroanatomical patterns between the three subtypes and CN. D) Effect size maps for the neuroanatomical patterns between the four subtypes and CN. E) Clinical characteristics for the two subtypes. Mann–Whitney–Wilcoxon test was used for continuous. The significance threshold is 0.05 and * denotes statistical significance. All continuous variables were normalized for visualization purposes. GAF: global assessment of functioning. We harmonized the low-dimensional components using the Combat-GAM model (Pomponio et al., 2019) to mitigate the site effect. Disease onset: age at onset.