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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Pain. 2022 Mar 1;163(3):508–517. doi: 10.1097/j.pain.0000000000002376

FIGURE 6. Microglial ablation by PLX6522 did not affect mechanical OIH in rats.

FIGURE 6.

A. PLX6522-mediated microglial ablatin in rat spinal cords. Male rats (Sprague-Dawley, 180–200g) were on PLX6522-containing diets for 5 days before the start (day 0) of morphine administration (20mg/kg; i.p./daily for 4 days). Spinal cords were collected at day 7. Marked decrease of spinal microglia (as indicated by Iba1 levels) was induced by PLX6522. B. Effect of PLX6522-mediated microglial ablation on OIH expression in male rats. PLX5622 administration did not affect the development of morphine-induced mechnical hypersensitivity in rats, measured by Von Frey tests. N=6 male rats/group; p>0.05 for PLX6522+Mor vs. Mor and Veh vs. PLX6522.