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Altered LPS-driven leukocyte gene expression mirrors plasma cytokine dysregulation in CVIDc. A, Global gene expression effect of LPS stimulation on PBMCs, showing CVIDc differs from the pattern shared between uncomplicated CVID and HCs. B, Gene set enrichment analysis comparing CVIDc against uncomplicated CVID and HCs grouped together. C, Heat maps of the hallmark inflammatory response and TNF signaling via NF-kB gene sets. *P < .05, **P < .01, ***P < .001.
