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Cytokine dysregulation of CVIDc corresponds with expansion and activation of circulating monocytes. A, Innate immune-cell subsets in whole blood by mass cytometry. (B) CD14+CD16− monocytes and (C) CD1c− dendritic cells as percentages of whole blood. D, Plasma TNF and CD14+CD16− monocyte correlation. E, CD86 and HLA-DR median intensity. *P < .05, **P < .01, ***P < .001, ****P < .0001.
