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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: J Allergy Clin Immunol. 2021 Jun 17;149(1):315–326.e9. doi: 10.1016/j.jaci.2021.06.008

FIG 5.

FIG 5.

CVIDc cytokine dysregulation corresponds with T-cell activation and infiltration of tissues. A and B, CD4+ and CD8+ T-cell subsets as percentages of whole blood. C, Plasma IL-12 correlation with CD4+ TCM cells. D, Representative CVIDc biopsies illustrating T-cell infiltration. E, Olink measurement of plasma chemokines. F, Luminex measurement of plasma CXCL10. G, Weight before and after immunomodulatory therapy (AZA 5 azathioprine, ABC 5 abatacept) in subjects with CVIDc. Data points are means with SD 3 weights measured before and after treatment. G, Ileum biopsies before and after abatacept in subject P22 with CVIDc. **P < .01, ***P < .001, ****P < .0001.