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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: J Allergy Clin Immunol. 2021 Jun 17;149(1):315–326.e9. doi: 10.1016/j.jaci.2021.06.008

FIG 6.

FIG 6.

Unsupervised machine learning reinforces link between cytokines, antibodies, and T cells in CVIDc. A, Partition around medoids (PAM) clustering of subjects with CVID and HC subjects. Subjects with CVID denoted by circles, HCs by triangles. Cluster x and y coordinates were determined by the Rtsne algorithm. Each dot is for 1 human subject, and its size indicates the number of subject’s noninfectious complications. B, Percentage of subjects with CVIDc assigned to cluster 1 and clusters 2 and 3. C, Percent contribution of parameters to the largest principle components (PC1) in which there is significant separation between subjects with CVID and HCs. Red dashed line indicates threshold of significant contribution.