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. 2021 Dec 3;9:767006. doi: 10.3389/fcell.2021.767006

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Copyright © 2021 Wang, Li, Li, Li, Gao, Bao, Wang, Liu, Xue and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Osteogenic differentiation and TAZ expression were increased by CCG treatment by increasing the p-ERK/ERK ratio. (A–C) Relative mRNA and protein levels to GAPDH of TAZ at Day 3 in different groups. (D–F) Relative mRNA and protein levels of p-ERK at Day 3 in different groups. (G, H) Representative images of AR-S showed the calcium deposits were influenced by CCG treatment. Scale bar: 100 μm *p < 0.05 vs. the control group (cells cultured in osteogenic medium during osteogenesis); #p < 0.05 vs. the CCG administration group.