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. 2021 Dec 3;14:742790. doi: 10.3389/fnmol.2021.742790

FIGURE 5.

FIGURE 5

RNA metabolism, chromatin organization and HNRNPs precursor’s display shortened APAs in the presence of WT tau. (A) Enrich-GO Biological Process of WT tau shortened APAs (p-value reported). (B) Partial list of biological process genes with shortened APAs upon presence of WT tau (mRNA processing, RNA splicing, chromatin remodeling and regulation of response to DNA damage). (C) The Cellular Components scatterplot is organized so that similar gene sets are clustered together. The larger blue points represent significantly enriched terms—the darker the blue, the more significant the term and the smaller the p-value. The gray points are not significant. Plots has been generated and downloaded using scatter plot visualization Appyter. (D) Enrich-GO Cellular Component of WT tau shortened APAs (p-value reported). Representative poly-A site usage for shortened poly-A tails from PAC-Seq of MATR3 (E) and EMB (F) transcripts. An asterisk (*) next to a p-value indicates the term also has a significant adjusted p-value (<0.05).