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. 2021 Dec 3;15:787362. doi: 10.3389/fnbeh.2021.787362

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Copyright © 2021 Minnig, Park, Echeveste Sanchez, Cottone and Sabino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of AAV-mediated short-hairpin virus knockdown of PAC1R in the NAcc Shell in Scr:sP rats on ethanol self-administration in an FR-1 schedule of reinforcement (n = 8/group). (A,B) Rats with NAcc Shell PAC1R shRNA knockdown (“AAV-PAC1R KD”) drank significantly more ethanol than control AAV rats (“AAV-CTRL”). (C,D) NAcc Shell AAV-PAC1R KD rats drank less water in later sessions. (E,F) NAcc Shell AAV-PAC1R KD rats also showed a higher preference for ethanol compared to AAV-CTRL rats. Data represent Mean ± SEM. ^∗p ≤ 0.05, ^∗∗p ≤ 0.01.