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. 2021 Dec 3;15:787362. doi: 10.3389/fnbeh.2021.787362

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Copyright © 2021 Minnig, Park, Echeveste Sanchez, Cottone and Sabino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of NAcc Shell PAC1R shRNA knockdown on motivation to drink alcohol in a progressive ratio schedule of reinforcement (n = 8/group). (A,B) Rats with NAcc Shell PAC1R shRNA knockdown (“AAV-PAC1R KD”) showed a higher breakpoint in the PR schedule, compared to control rats (“AAV-CTRL”). (C,D) NAcc Shell AAV-PAC1R KD rats also displayed higher lever presses for ethanol, compared to AAV-CTRL rats. (E,F) AAV-CTRL rats pressed the inactive lever more often than NAcc Shell AAV-PAC1R KD rats. Data represent Mean ± SEM. ^∗p ≤ 0.05.