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. 2021 Dec 3;15:787362. doi: 10.3389/fnbeh.2021.787362

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Copyright © 2021 Minnig, Park, Echeveste Sanchez, Cottone and Sabino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of NAcc Shell PAC1R shRNA knockdown on PAC1R levels in the NAcc Shell of rats (n = 6/group). (A,B) Representative images of PAC1R (red) and GFP (green) expression in the NAcc Shell of AAV-CTRL and AAV-PAC1R KD rats (C) NAcc Shell PAC1R shRNA knockdown rats (“AAV-PAC1R KD”) showed a significant reduction in the number of PAC1R positive cells in the NAcc Shell, compared to AAV controls (“AAV-CTRL”). (D) NAcc Shell PAC1R shRNA knockdown also significantly reduced the number of PAC1R positive cells specifically in virally infected cells (GFP-labeled cells). White arrows point to example PAC1R-labeled cells. Scale bars represent 100 μm. Data represent Mean ± SEM. ^∗∗∗p ≤ 0.001.