Figure 6.

Cases with genomic and spatial-temporal evidence for nosocomial transmission. SNP tree branches from the NCBI Pathogen Detection Isolates Browser are overlaid with the isolate identifier, de-identified patient number, and day within the study that the sample was collected. The key at the bottom indicates cases and sample types from which Clostridioides difficile was isolated. Arrows indicate potential transmission events based on genomic and hospital epidemiologic analyses of patient hospital location data. A–F, Example cases. Text boxes summarize supporting spatial and temporal information from integrated genomic-epidemiologic analyses. Abbreviations: CDI, Clostridioides difficile infection; ICU, intensive care unit; NCBI, National Center for Biotechnology Information; SNP, single nucleotide polymorphism; VRE, vancomycin-resistant enterococci.