TABLE 3.
Enhancing stem cell function using instructive biomaterials and mechanotransduction.
| Biomaterial | Cell/tissue type | Observed effect | References |
|---|---|---|---|
| Collagen-based hydrogels | MSCs | Osteogenic differentiation ↑ | Lou et al. (2018) |
| Hydrogels with tunable dissociation rate constant | MSCs | Spreading ↑ | Yang et al. (2021) |
| Osteogenic differentiation ↑ | |||
| Hydrogels | MSCs | alpha-SMA marker ↑ | Cameron et al. (2011) |
| Calponin ↑ | |||
| Alginate-based hydrogels | hMSCs | Osteogenic differentiation ↑ | Darnell and Mooney, (2017) |
| Biomineralization ↑ | |||
| Matrix secretion ↑ | |||
| Cell retention ↑ | |||
| RGD-PEG-PLA nanoparticles | hMSCs | Cell retention Cell viability ↑ | Grosskopf et al. (2020) |
| Cell engraftment ↑ | |||
| HA-based hydrogels | ADSCs | Cell retention ↑ | Andreina Parisi-Amc et al., 2013 |
| PINIPAM-C7-based hydrogels containing YIGSR, IKVAV | Schwann cells | Cell retention ↑ | Marquardt et al. (2020) |
| PEG-based hydrogels | Chondrocytes | ECM secretion ↑ | Richardson et al. (2019) |
| GAG secretion ↑ | Feng et al. (2019) |
PINIPAM, poly(N-isopropyl acrylamide); HA, hyaluronic acid; MSCs, mesenchymal stem cells; YIGSR, (Tyr-Ile-Gly-Ser-Arg); IKVAV, (Ile-Lys-Val-Ala-Val); ECM, extracellular matrix; GAGs, glycosaminoglycans; α-SMA, alpha-smooth muscle actin; PEG, poly(ethylene glycol); hMSCs, human mesenchymal stem cells.