TABLE 4.
Enhancing stem cell retention using instructive biomaterials.
| Biomaterial | Bioactive cue | Cell/tissue type | Observed effect | References |
|---|---|---|---|---|
| PLCL/heparin nanofibers | SDF-1α | c-kit positive cells ↑ | Shafiq et al. (2017) | |
| BMSCs ↑ | ||||
| Blood vessels ↑ | ||||
| Microbubbles | SDF-1α | BMSCs | CXCR4 ↑ | Xiang et al. (2020) |
| Cell migration ↑ | ||||
| PLGA/HA NPs | SDF-1α | MSCs | SDF-1α release ↑ | Teo et al. (2020) |
| CXCR4 ↑ | ||||
| Transendothelial cell migration ↑ | ||||
| Biodistribution ↑ | ||||
| PLGA-HA NPs | EGCG, MnO2 nanocatalysts | MSCs | Metabolic potential ↑ | Teo et al. (2020) |
| Angiogenesis ↑ | ||||
| Octadecylamine-grafted HA-encapsulating liposomes | TNF-α-encapsulating liposomes | ADSCs | VEGF ↑ | Leong et al. (2020) |
| PGE2 ↑ | ||||
| Vascularization ↑ Pigment epithelium-derived growth factor ↑ | ||||
| PCL scaffolds | GDNF, BDNF | NSCs | Perfusion ↑ | Wang et al. (2016) |
| Cell survival ↑ | ||||
| Cell proliferation ↑ | Nisbet et al. (2018) | |||
| Neurites outgrowth ↑ | ||||
| SAP-based hydrogels | GFs | Astroglia ↓ | Bruggeman et al. (2017) | |
| Growth factors release ↑ | ||||
| APICLS | Paracrine factors | MSCs | Angiogenesis ↑ | Park et al. (2018) |
| Cardioprotection ↑ | ||||
| Contractile forces ↑ | ||||
| Cardiac remodeling ↓ | Park et al. (2020a) | |||
| Fibrosis ↑ | ||||
| Decellularized omentum tissues | iPSCs-CMs | MSCs | Cell survival ↑ | Gal et al., 2020 |
| Cell retention ↑ | ||||
| PPZ-based hydrogels | TGF-β-derived peptides | MSCs | Cell survival ↑ | Hong et al. (2019) |
| CESPLKRQ & HAV | Chondrogenesis ↑ | |||
| Oxygen-preserving hydrogels | HEMA | BMSCs | Cell survival ↑ | Niu et al. (2020) |
| Cell proliferation dsDNA content of cells ↑ | ||||
| PCL/Col-1 nanofibers | SP, IGF-1C | - | Cell mobilization ↑ | Shafiq et al. (2018) |
| Vascularization ↑ | ||||
| Cardiac function ↑ |
PLCL, poly(L-lactide-co-caprolactone); PLGA, poly(L-lactide-co-glycolide); PCL, polycaprolactone; Col-1, collagen type 1; HA, hyaluronic acid; NPs, nanoparticles; SAP, self-assembling peptides; PPZ, poly(organophosphazene); SDF-1α, stromal cell-derived factor 1 alpha; BDNF, brain-derived neurotrophic factor; GDNF, glial-derived neurotrophic factor; iPSC-CMs, induced pluripotent stem cell-derived cardiomyocytes; TGF-β, transforming growth factor-beta; MSCs, mesenchymal stem cells; BMSCs, bone marrow mesenchymal stem cells: HEMA, 2-hydroxyethyl methacrylate.