Table 2.
Demographics, clinical and laboratory parameters in hemodialysis patients and kidney transplant recipients presented as responders versus non responders in each group after the second dose of vaccine.
Hemodialysis patients (n = 34) | p | Kidney Transplant Recipients (n = 54) | p | |||
---|---|---|---|---|---|---|
Responders (n= 31) | Non-Responders (n=3) | Responders (n=16) | Non-Responders (n=38) | |||
Age, yr | 69.2 ± 12 | 71.3 ± 17.6 | 0.78 | 55.01 ± 2.23 | 59.5 ± 7.48 | 0.18 |
Male sex | 22, 71.0% | 1, 33.3% | 0.24 | 13, 81.3% | 25, 65.8% | 0.26 |
BMI, kg/m2 | 25.23 ± 4.19 | 23.77 ± 2.86 | 0.56 | 25.85 ± 3.99 | 25.98 ± 4.05 | 0.92 |
Diabetes mellitus | 7, 22.6% | 2, 66.7% | 0.16 | 3, 18.7% | 7, 18.4% | 0.98 |
History of Cancer | 1, 6.7% | – | 1, 6.2% | 4, 10.5% | 0.62 | |
Time on dialysis, years | 5.81 ± 4.88 | 4.66 ± 1.53 | 0.69 | |||
Time from Transplant, years | 12.94 ± 9.62 | 11.45 ± 7.70 | 0.55 | |||
Donor type | ||||||
Deceased | 9, 56.2% | 26, 68.4% | 0.55 | |||
Live | 7, 43.8% | 11, 28.9% | ||||
Both | – | 1, 2.6% | ||||
ABO group | 0.57 | 0.27 | ||||
A | 10, 32.2% | 2, 66.7% | 4, 25.0% | 17, 47.2% | ||
AB | 2, 6.5% | – | – | 2, 5.6% | ||
B | 8, 25.8% | 1, 33.3% | 2, 12.5% | 5, 13.9% | ||
O | 11, 35.5% | – | 10, 62.5% | 12, 33.3% | ||
Hb, g/dl | 10.97 ± 1.00 | 9.37 ± 1.01 | 0.013 | 14.11 ± 1.85 | 13.30 ± 1.88 | 0.15 |
WBC, 103/ml | 8326 ± 10050 | 6496 ± 4010 | 0.76 | 7961 ± 2751 | 8277 ± 2663 | 0.69 |
Tacrolimus | 10, 62.5% | 31, 81.6% | 0.13 | |||
Cyclosporine | 6, 37.5% | 7, 18.4% | 0.13 | |||
MMF/MPA | 12, 75.0% | 38, 100.0% | 0.006 | |||
Steroids | 12, 75.0% | 34, 89.5% | 0.17 | |||
Tacrolimus+MMF/MPA | 8, 50.0% | 31, 81.6% | 0.018 | |||
Tacrolimus+MMF/MPA+Steroids | 7, 43.8% | 28, 73.7% | 0.035 | |||
Tacrolimus levels, ng/ml | 6.2 ± 1.7 | 6.8 ± 1.2 | 0.24 | |||
Cyclosporine T0 levels, ng/ml | 102.6 ± 19.2 | 104.5 ± 26.0 | 0.88 | |||
eGFR, ml/min per 1.73m2 | 61.6 ± 15.4 | 48.9 ± 17.2 | 0.014 | |||
Urine Protein, mg/24h | 307 ± 550 | 339 ± 345 | 0.80 |
BMI, body mass index; CNI, calcineurin inhibitor; eGFR, estimated glomerular filtration rate; MMF, mycophenolate mofetil; MPA, mycophenolic acid.