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. 2021 Dec 3;8:783301. doi: 10.3389/fmolb.2021.783301

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Copyright © 2021 Vasconcelos, Estrada, David, Wermelinger, Almeida and Zingali.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sequence alignments of representative disintegrins. The sequences were obtained through research in the Blast software (Altschul et al., 1990; Gish and States, 1993). The pink color highlights the sequence signatures, green the residues that are not conserved within the signatures, orange the cysteines. Dotted blue squares show the conserved L/I that compose the hydrophobic core. RGD/KGD or related three-peptides are underlined. The codes representing the sequences were obtained from PDB and UniProt. Abbreviated: VAP-1 (Vascular apoptosis-inducing protein 1); RRV-X (Russell’s viper venom factor X activator); EcoHIT (Viper PIII hemorrhagic SVMP Echis coloratus); EcH (Metalloproteinase Echis pyramidum leakeyi); Gloydius shedaoensis (G. shedaoensis); SSV (saw-scaled Viper). The multiple sequence alignment was performed using the ClustalW2 server (https://www.genome.jp/tools-bin/clustalw).