Skip to main content
. 2021 Dec 3;12:769929. doi: 10.3389/fphar.2021.769929

TABLE 2.

Chemical structures of pharmacologically investigated metabolites with corresponding activities of liriopogons (details of activities can be found in Table 3).

Metabolite Chemical structures Investigated pharmacological activity
Ruscogenin graphic file with name fphar-12-769929-fx1.jpg Cardiovascular protective, anti-inflammatory, effects on the endocrine system, Immunomodulation, anti-cancer
Ophiopogonin D graphic file with name fphar-12-769929-fx2.jpg Cardiovascular protection, anti-inflammation, effects on the endocrine system, anti-oxidation, cytotoxicity, anticancer, anti-tussive
Ophiopogonin D′ graphic file with name fphar-12-769929-fx3.jpg Cytotoxicity, anti-cancer
DT-13 graphic file with name fphar-12-769929-fx4.jpg Carddiovascular protection, anti-cancer, immunomodulation, cytotoxicity, anti-cancer, anti- acute myeloid leukemia
Sprengerinin C graphic file with name fphar-12-769929-fx5.jpg Anti-cancer
Diosgenin-3-O-[2-O-acetyl-α-l-rhamnopyranosyl-(1→2)][β-d-xylopyranosyl-(1→4)]-β-d-glucopyranoside (Metabolite 26) graphic file with name fphar-12-769929-fx6.jpg Anti-cancer
Ophiopogon saponin C1 graphic file with name fphar-12-769929-fx7.jpg Anti-cancer
Spicatoside A graphic file with name fphar-12-769929-fx8.jpg Anti-inflammation, anti-viral
Methylophiopogonone A graphic file with name fphar-12-769929-fx9.jpg Anti-inflammation
Methylophiopogonanone A (MONA) graphic file with name fphar-12-769929-fx10.jpg Cardiovascular protection, effects on the endocrine system
Methylophiopogonanone B graphic file with name fphar-12-769929-fx11.jpg Cardiovascular protection, anti-inflammation, cytotoxicity
(3R)-3-(2′,4′-dihydroxybenzyl)-5,7-dihydroxychroman-4-one graphic file with name fphar-12-769929-fx12.jpg Cardiovascular protection
(Metabolite 209)
 (3R)-3-(2′,4′-dihydroxybenzyl)-5,7-dihydroxy-6-methyl-chroman-4-one graphic file with name fphar-12-769929-fx13.jpg Cardiovascular protection
(Metabolite 210)
 4′-O-Demethylophiopogonnaone E graphic file with name fphar-12-769929-fx14.jpg Anti-inflammation
 Ophiopogonone E graphic file with name fphar-12-769929-fx15.jpg Anti-inflammation
 Ophiopogonanone H graphic file with name fphar-12-769929-fx16.jpg Anti-inflammation
 (2R)-(4-methoxybenzyl)-5,7-dimethyl-6-hydroxyl-2,3-dihydrobenzofuran graphic file with name fphar-12-769929-fx17.jpg Anti-inflammation
 2-(2-hydroxyl-4-methoxy-benzyl)-5-methyl-6-methoxyl-2,3-dihydrobenzofuran graphic file with name fphar-12-769929-fx18.jpg Anti-inflammation
 8-formylophiopogonanone B (FOB-8) graphic file with name fphar-12-769929-fx19.jpg Anti-oxidation
 (3R)-3-(4′-hydroxybenzyl)-5,7-dihydroxy-6-methyl-chroman-4-one (Metabolite 207) graphic file with name fphar-12-769929-fx20.jpg Anti-viral
 58-F graphic file with name fphar-12-769929-fx21.jpg Hepatoprotection
 oleic acid graphic file with name fphar-12-769929-fx22.jpg Cardiovascular protective, anti-inflammatory, effects on the endocrine system, immunomodulation, anti-cancer
 syringic acid graphic file with name fphar-12-769929-fx23.jpg Cardiovascular protection, anti-inflammation, effects on the endocrine system, anti-oxidation, cytotoxicity, anti-cancer, anti-tussive effect