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. 2021 Dec 3;12:766024. doi: 10.3389/fphar.2021.766024

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Copyright © 2021 Yang, Wang, Yao, Xiong, Wang, Fang, Yang, Jiang, Song, Liu and Qian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OT alleviated cardiac hypertrophy caused by ISO administration along with up-regulation of lncRNA GAS5 expression. SD rats were treated with ISO and different concentrations of OT as described. (A) HW/BW ratio. (B−D) The expressions of BNP, β-MHC and α-SMA mRNA detected by qRT-PCR. (E) Quantitative morphometric analysis of Masson’s trichrome staining representing myocardial fibrosis. (F) Effects of OT (3 ug/kg) postconditioning on the expression of lncRNA GAS5. (G) Representative histopathological images of heart tissue sections stained with H&E, Masson’s Trichrome staining from the indicated groups. n = 3–6 rats per experimental group. Data shown as mean ± sd, *p < 0.05 **p < 0.01.